(-)-6-Chloro-2-[(1-furo[2, 3-c]pyridin-5-ylethyl)thio]-4-pyrimidinamine, PNU-142721, a new broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitor

MeSH terms

• Animals
• Anti-HIV Agents / chemical synthesis
• Anti-HIV Agents / pharmacokinetics
• Anti-HIV Agents / pharmacology*
• Cell Line
• Drug Resistance, Microbial
• HIV Reverse Transcriptase / antagonists & inhibitors
• HIV Reverse Transcriptase / genetics
• HIV-1* / drug effects
• HIV-1* / enzymology
• Male
• Mutation
• Pyridines / chemical synthesis
• Pyridines / pharmacokinetics
• Pyridines / pharmacology*
• Pyrimidines / chemical synthesis
• Pyrimidines / pharmacokinetics
• Pyrimidines / pharmacology*
• Rats
• Rats, Sprague-Dawley
• Reverse Transcriptase Inhibitors / chemical synthesis
• Reverse Transcriptase Inhibitors / pharmacokinetics
• Reverse Transcriptase Inhibitors / pharmacology*
• Stereoisomerism